Cancer is a major health issue worldwide, largely due to the rapid spread of abnormal cells. These cells often form tumors, like carcinomas, which come from epithelial cells growing out of control. Tumors release growth factors such as FGF and VEGF. These factors help new blood vessels form, a process called angiogenesis. This process is crucial for tumor growth and spreading. Heparanase is an enzyme that breaks down heparan-sulfate proteoglycans, which are important for cell communication and structure. This breakdown aids in tumor progression and metastasis.

Chitosan, a derivative of chitin, has shown potential in fighting tumor growth and spread. Researchers have created new sulfated chitosan oligomers that mimic heparin. These mimics are designed to block heparanase. The goal is to see if these new compounds can stop cancer cells from growing and spreading. The study focused on four types of cancer cells: SH-SY5Y, HCT116, A549, and MDA-MB-231.

To predict and validate the effects of these new compounds, researchers used a variational quantum neural network (VQNN). This advanced method combines quantum computing with machine learning. The VQNN analyzed how well the sulfated chitosan oligomers worked against cancer cells. Lab experiments backed up the model's predictions, showing it could accurately forecast the compounds' effects.

The VQNN model performed well, with a mean absolute error (MAE) of 6. 5844. This means its predictions were close to the actual results. The model also had an R

2

 value of 0. 6020, showing a decent match between predicted and observed outcomes. This success highlights the potential of using quantum-based machine learning in cancer research. Such models could speed up drug discovery by quickly identifying and improving new treatments. This approach could lead to better cancer therapies that target tumor growth and blood vessel formation.

The findings support the use of quantum computing in solving complex biological problems. This could lead to new strategies for treating cancer more effectively. The use of quantum computing in medicine is still in its early stages. However, its potential to revolutionize cancer treatment is clear. By integrating quantum-based models, researchers can gain deeper insights into cancer biology. This could pave the way for more targeted and effective treatments.

HEPARANASE INHIBITOR RESEARCH

Sulfated Chitosan: A New Hope in Cancer Treatment?

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