The heart works harder during physical activity. This fact is crucial for people with aortic coarctation (CoA). CoA is a narrowing of the aorta, the main artery carrying blood from the heart. Doctors often measure the pressure difference (ΔP) across this narrowing to gauge its severity. However, standard tests might not show the full picture.

Traditional methods, like cardiac catheterization, require anesthesia. They also don't show how daily activities affect the heart. This can lead to an underestimation of how bad the condition really is. To tackle this, researchers turned to a hybrid mock circulatory loop (HMCL). This setup mimics the body's blood flow and pressure changes during rest and exercise.

The team used 4D-Flow MRI scans to create patient-specific aorta models. These models were then 3D-printed to make realistic aortic replicas. These replicas were integrated into the HMCL, allowing for precise measurements of ΔP during simulated exercise. The results were striking. The pressure difference increased in a non-linear way with cardiac output, varying from person to person.

To validate their findings, the researchers also ran fluid-structure interaction (FSI) simulations. These computer models showed excellent agreement with the HMCL results. This means that FSI simulations can be used alone to assess how exercise affects CoA. This is a big deal because it makes the process less complex and more accessible.

The study highlights the importance of looking beyond resting measurements. Exercise-induced changes in ΔP can reveal more about the true impact of CoA. This approach could lead to better, more personalized treatments. It also shows the potential of advanced simulations in medical research. By using these tools, doctors can gain deeper insights into how diseases affect the body during daily activities.

HYBRID MOCK CIRCULATORY LOOP

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