The CD70 and CD27 proteins are key players in the immune system's fight against cancer. They work together to activate and multiply T cells, which are crucial for attacking cancer cells. However, in cancer, this partnership can backfire. Prolonged interaction between CD70 and CD27 can exhaust and even kill T cells, making them ineffective against the tumor. This is a...
The UFO method is a new way to figure out the best dose for immunotherapy treatments. It's all about finding the sweet spot where the medicine works well but doesn't cause too many side effects. This method doesn't use complicated math models. Instead, it looks at how different types of results are connected. It considers things like how the body responds to the trea...
Pancreatic cancer is a serious disease that can be very aggressive and harmful to health. Traditional chemotherapy can be effective, but it often comes with harsh side effects. This has sparked interest in finding better ways to treat this cancer. One promising area of research is the use of nanomaterials. These tiny particles have the potential to target cancer cell...
Lung cancer is a serious issue, and small-cell lung cancer (SCLC) is one of the trickier types. It often spreads quickly, making it hard to treat. Doctors have been looking for better ways to fight it. One approach is to use a mix of drugs that work together to attack the cancer from different angles. This is where carboplatin, etoposide, atezolizumab, and bevaci...
Cancer treatment has seen a major boost with the introduction of allogeneic cell-based therapies. These treatments, especially CAR-T cell therapy, are a big deal because they can be made in large quantities and are consistent. However, there is a significant hurdle: graft-versus-host disease (GvHD). This occurs when the transplanted cells attack the patient's body. R...
Cancer treatment has seen a major shift with the introduction of immune checkpoint blockade. This method has led to significant improvements in long-term outcomes and survival rates, especially when combined with other treatments. However, not everyone benefits from these treatments. Some patients face serious side effects. This is due to the complexity of cancer, wh...
In the world of cancer treatment, a new approach is making waves. This approach is immunotherapy. It is a treatment that can help some patients avoid the harsh effects of traditional treatments like surgery, chemotherapy, and radiation. This is big news for those with certain types of cancer. The story of Maureen Sideris is a great example. She was diagnosed with ga...
Climate change is making allergies worse. It is altering the environment in ways that affect how plants and fungi grow and spread. This shift is making pollen and spores more potent. The changes are causing more people to suffer from allergies and related health issues. The air we breathe is changing. Higher temperatures and more frequent extreme weather events are ...
Kidney cancer is a serious health concern. Around 70% of kidney cancer cases are clear cell renal cell carcinoma (ccRCC). Surgery is the go-to treatment for this type of cancer. But, it comes with risks. Patients often face kidney damage and a high chance of cancer spreading to other parts of the body. This makes life tough for those who unde...
First, let us understand the big picture. Immunotherapy has transformed the way doctors fight advanced liver cancer. This is great news. However, it is not all sunshine and roses. These treatments can cause serious heart problems. These issues can make the treatment less effective. Doctors call these problems cardiological adverse events or MACE. These can be ...