Imagine you're trying to understand how your body's immune system affects liver cancer. It's a complex puzzle, right? Researchers have been studying the tiny immune cells that live near liver tumors. These cells play a big role in how cancer grows and how well treatments work. Scientists looked at a bunch of liver cancer samples from different databases and real-lif...
Imagine a tiny, smart bomb designed to wipe out cancer cells and wake up the body’s immune system to fight back. This is the idea behind a new nanogel drug delivery system, DPCLG. It’s like a sneaky military operation, targeting two types of cells in the tumor’s neighborhood: cancer cells and immune cells that have been fooled into helping the tumor grow. First, the...
Pulmonary sarcomatoid carcinoma (PSC) is an unusual kind of lung cancer that quickly spreads and invades tissues. Typically, it's found at later stages, making surgery challenging. There's no clear best treatment for advanced PSC. Researchers looked at how well chemotherapy and immunotherapy-based treatments work for these patients. Researchers used data from the SE...
Treatment options for epithelial ovarian cancer (EOC) have expanded a lot in recent years, but much of the progress has been tied to picking the right biomarkers. This means there's still a big need for better treatment options to help patients live longer and enjoy better quality of life. Unlike many other types of cancer, using immune checkpoint inhibitors (CPIs) a...
Imagine you're battling advanced biliary tract cancer (ABTC), and your doctors suggest a mix of drugs: nivolumab, modified gemcitabine, and S-1. This combo showed promise in a past trial, but PD-L1 levels didn't tell us much about how well it would work. So, scientists looked at another marker, LAG-3. They studied 44 tumor samples, staining them for both PD-L1 and LA...
Immune treatments, or immune checkpoint inhibitors (ICIs), are game-changers for some people with far-advanced solid tumors. But when it comes to biliary tract cancer (BTC), doctors are still figuring out who gets the most benefit from these treatments. A recent trial focused on pembrolizumab, an ICI, to better understand who will respond best to this therapy in adva...
Cancer remains one of the world's leading causes of death. Despite years of research, it's still a complex disease that needs a cure. While traditional cancer treatments have been used for a long time, they aren't always effective or easy to use. That's why scientists are looking for better ways to treat cancer. One new approach is called CAR-T cell therapy. In this ...
Imagine this: a brain chemical that messes with your mood also plays a big role in cancer. That’s what researchers found out about something called Monoamine Oxidase A, or MAO-A. This stuff is like a switch that can turn immune cells from sleepy to superhero in tumors. Normally, MAO-A breaks down brain chemicals that control mood. But in tumors, it changes the behavi...
Acute myeloid leukemia (AML) is a tough nut to crack. It's the leukemic stem cells (LSC) that often cause relapses, making them a prime target for research. One approach gaining attention is radioimmunotherapy. This method uses radioactive isotopes to deliver a punch to these cells. The idea is simple: ionizing radiation (IR) can kill LSC, even if they lack specific ...
Cytotoxic T lymphocytes (CTLs) are crucial for fighting cancer, but many people with liver cancer (HCC) who have lots of these cells still face early relapse or resistance to treatments. Scientists don't fully understand why this happens. They studied 20 patients with liver cancer and CTLs to figure out what's going on. They used special stains to look at single cell...