Fungi are not just for pizza toppings or fairy tales. Some fungi can actually help fight nasty parasites. One such fungus is Metarhizium anisopliae. Scientists have been testing a specific strain, IBCB425, to see if it can tackle a common worm problem in sheep. This worm, Haemonchus contortus, is a real pain for farmers. It causes disease and can even kill sheep if left unchecked.

First, they tested it in labs. They mixed worm eggs with different amounts of the fungus. After ten days, they checked how many worm larvae were still alive and moving. The results were promising. Higher doses of the fungus reduced the number of lively larvae. This suggested that the fungus could be effective in controlling the worm population.

Next, they moved to the field. They created small plots on a paddock and contaminated them with worm eggs. Then, they sprayed the fungus on these plots. Thirty days later, they collected grass samples to see if the fungus had any effect. The highest dose of the fungus reduced the movement of the worm larvae. This was a good sign that the fungus could work in real-world conditions.

However, when they tested it on a paddock with actual sheep, the results were not as clear. They sprayed the fungus on one plot and left another as a control. They collected grass samples before and after spraying. They also had sheep graze on these plots to see if the fungus affected the worm counts in the sheep's stomachs. Unfortunately, they didn't see any significant differences. This could mean that the fungus doesn't work as well in real-world conditions with live animals. It could also mean that the fungus needs to be applied differently or in different amounts.

One interesting finding was that the worm larvae from both the treated and untreated plots were moldy. This might suggest that the fungus can survive in the sheep's gut, but it's not clear if this is a good or bad thing. It could mean that the fungus is effective, or it could mean that it's not doing enough to control the worm population.

The use of fungi to control parasites is an exciting area of research. It could lead to new, eco-friendly ways to manage pests in agriculture. However, more work is needed to understand how to use these fungi effectively. Scientists need to figure out the best doses, application methods, and conditions for these fungi to work their magic. It's a complex problem, but the potential benefits make it worth the effort.

IN VITRO AND IN VIVO

Fighting Worms with Fungi: A New Approach

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