Accurately estimating the future sales of drugs that are already on the market, known as post-revenue assets, is a big deal in the pharmaceutical world. It helps companies like Pfizer make smart decisions about where to invest their money. This study introduces a new way to forecast these sales by u
Imagine a hidden battle playing out in the rivers of Curitiba, Brazil. The culprits? Three drugs—azithromycin, ivermectin, and hydroxychloroquine—used widely during the COVID-19 pandemic. Scientists dove into this issue, finding alarming levels of these medicines in both water and sediment from urba
Ever wondered how cells communicate? One key player is something called cyclic AMP (cAMP). It's like a messenger that tells cells what to do. But sometimes, enzymes called phosphodiesterases (PDEs) break down cAMP, and that can cause trouble. Scientists have been trying to stop these PDEs, but their
Diabetic macular edema is a serious eye condition that can lead to vision loss. While clinical trials often show promising results, real-world treatment can be tough. Patients, healthcare providers, and clinic staff all face hurdles that make managing this condition difficult. These problems can inc
In the heart of the Renaissance, the office of the Venetian Doge produced a wealth of official documents. These records offer a deep dive into the worlds of history, diplomacy, and culture. One such document is a ducal letter penned by Francesco Donato, the Doge of Venice, in the 16th century. This
Megan Fox and Machine Gun Kelly, whose real name is Colson Baker, have reportedly split up. The news comes after Fox allegedly found something disturbing on Baker's phone during Thanksgiving weekend in Colorado. This is not the first time the couple has faced challenges. Last year, they called off t
Social anxiety disorder (SAD) affects many people. It makes them very scared of social situations. Doctors need to detect SAD early to help people sooner. But this is hard because those with SAD avoid social settings. Also, questionnaires used now have problems like personal opinions influencing res
Machine learning (ML) has become a go-to tool in hospitals for predicting clinical risks. But here's a big challenge: these models don't always work as well over time. Why is that? The systems and data these models rely on are constantly changing, which can make the predictions less accurate. This c
Mild autonomous cortisol secretion, or MACS, is a condition where the body produces too much cortisol on its own. But how does this affect our thoughts and memory? A recent study set out to answer this question. They wanted to find out how MACS influences cognition and what factors might lead to low
Hemodialysis machines are big players in the healthcare world, but they’re also big contributors to its carbon footprint. Surprisingly, about 100, 000 of these machines reach the end of their life cycle each year. That's like retiring a small city's worth of machines! Imagine if we could breathe new
