Patients with os odontoideum, a congenital neck anomaly, show a surprisingly high load of genetic changes. Researchers counted these alterations across the entire genome and found that affected individuals carry more mutations than people with typical neck anatomy. The study examined the DNA f
Cancer treatment has seen a major shift with the introduction of immune checkpoint blockade. This method has led to significant improvements in long-term outcomes and survival rates, especially when combined with other treatments. However, not everyone benefits from these treatments. Some patients f
Lung cancer is a tricky beast. It often hides from the immune system, making it tough to treat. But there's a glimmer of hope. Some lung cancers have a high number of mutations, which should make them easier for the immune system to spot. These are called TMB-H cancers. However, about 30% of these c
