Depression is often seen as a silent partner in the worsening of Alzheimer's disease. It's like a hidden force that makes things worse, but how it does this has been a bit of a mystery. Scientists have known that tiny brain helpers called microglia play a big role in both depression and dementia. But the exact way they team up to make Alzheimer's worse has been uncle...
Alzheimer's disease is a major health concern, and its progression is often linked to persistent brain inflammation. One interesting fact is that what we eat can either fuel or calm this inflammation. This is where the idea of an anti-inflammatory diet comes in. It's a way of eating that focuses on foods known to reduce inflammation in the body. The big question is:...
Schizophrenia is often seen as a puzzle of the mind. It is usually tied to chemical imbalances in the brain. However, recent findings suggest that brain inflammation might play a big role in this disorder. This inflammation can cause several issues. It can activate certain brain cells too much. It can also increase harmful substances in the brain. It can even break d...
Perioperative neurocognitive disorder (PND) is a big problem for older folks after surgery. It's like their brains take a hit, and there aren't many good ways to fix it. Scientists have spotted two things that might be involved: less of a substance called adiponectin (APN) in the blood and more lactate in the brain fluid. APN is known for helping with insulin resista...
Chemotherapy is a tough journey. It can mess with your brain, causing memory lapses, trouble focusing, and even feelings of depression and anxiety. This is often called "chemo brain. " Now, there's a drug called rosuvastatin, usually used to lower cholesterol, that might help with this issue. It works by inhibiting an enzyme called HMG-CoA reductase. Scientists wante...
The human body is built for movement, but pushing it too hard can backfire. Over the years, people have lived longer. This has made it super important to take care of our bodies. Exercise is a big part of that. However, too much of a good thing can be harmful. Excessive exercise can lead to muscle damage and even addiction to working out. This is where things get t...
Neutrophils are tiny warriors in our bloodstream. They are the most common type of white blood cell. They play a big role in what happens when the brain gets hurt. When the central nervous system is injured, these cells rush to the scene. They can either help or harm the healing process. This is where a protein called CD177 comes into play. It is found on the surface...
The choroid plexus (ChP) is a small but mighty structure in the brain. It's like a bouncer at a club, deciding who gets in and who stays out. During brain inflammation, the ChP has a big job. It controls how the brain talks to the body, making sure the immune system responds just right—not too much, not too little. The ChP is a barrier between the blood and the cere...
Brain inflammation, a significant factor in neurodegenerative diseases, is managed by tiny immune cells called microglia. These cells can be pro-inflammatory (M1) or anti-inflammatory (M2). We know that human stem cells from umbilical cords (hUCMSCs) can release substances that reduce inflammation. Another interesting method is photobiomodulation (PBM), which uses li...
Ever heard of mesencephalic astrocyte-derived neurotrophic factor (MANF)? It's a brain protein that might be a game-changer in the fight against Parkinson's disease (PD). PD is the second most common brain disorder that causes dopamine neurons in the brain to die off over time. One of the main culprits is a protein called α-synuclein (SNCA), which can clump together ...