Oral cancer is a serious issue, and one type, oral squamous cell carcinoma, is quite common. For those who have had surgery and radiation, there is a treatment option called anti-PD1 therapy. This therapy uses the body's immune system to fight cancer. However, not everyone responds well to this treatment. So, researchers looked for ways to predict who might benefit f...

In the world of mouth cancer, there is a lot of talk about how cells grow and spread. One interesting player in this game is something called guanylate binding protein 5, or GBP5. This protein has been studied for its role in fighting infections and helping the immune system. But here is where it gets tricky. Its part in cancer, especially in mouth cancer, is not wel...

Scientists have found some interesting things about DNA damage repair genes in people with oral cancer in Pakistan. They looked at five specific genes: TP53, ATR, ATM, CHEK1, and CHEK2. Using advanced tools, they found 42 mutations, with some being completely new. Out of these, 28 were nonsynonymous single nucleotide variations (SNVs). The gene TP53 had the most mut...

These tiny particles, called extracellular vesicles, are everywhere. They are released by cells throughout the body. This can be normal, or it can happen during disease. Even more interesting, these tiny particles can send signals to other cells. They can help start, grow, and spread cancer. One cancer they are known for aiding is a type of cancer in the mouth and t...