Osteogenesis imperfecta (OI) is a rare genetic condition that affects the body's connective tissues, making bones unusually fragile. This condition is usually identified through clinical observations, but genetic testing can provide additional insights. In Romania, a group of nine patients with type I OI were studied between 2021 and 2024. These patients were seen a...

Brittle bone disorders, or FBDs, can cause people to break bones easily. Scientists are trying to figure out which genes are responsible for these conditions. One way they are doing this is by studying zebrafish. These tiny fish share many bone-building genes with humans. Researchers used a tool called CRISPR to mess with the genes in zebrafish embryos and see how it...

Scientists often use stem cells to make artificial bones, but making sure these cells develop properly can be tricky. They've tried using omics technologies, like metabolomics, to check their quality. In a recent study, researchers combined metabolomics with machine learning to see if it could tell the difference between stem cells that became bone-like and those tha...

Osteogenesis Imperfecta (OI), often called "brittle bone disease, " is a rare genetic condition that makes bones very fragile. It's caused by a problem with a type of collagen, which affects different tissues in the body. Because OI impacts many body systems, people with it need care from many doctors. Kids with OI get a lot of attention and treatments, like medicin...