Scientists have created a clever way to deliver DNA into single cells using tiny glass tools called nanopipettes. These tools are special because they can release DNA on demand, thanks to a clever trick involving pH levels. The key to this innovation is something called an i-motif. This is a piece
Ever wondered how genes turn on and off? It's all about the packaging of DNA, called chromatin. Scientists have been trying to figure out how this process works, but it's been a tough nut to crack. Now, a new method called Dam&ChIC is here to change the game. Dam&ChIC is like a time machine for cel
B-cell acute lymphoblastic leukemia (B-ALL) is a complex disease. Scientists have been trying to understand how the origins of these cells affect how the disease behaves and how well treatments work. A recent study took a deep dive into this topic using advanced technology to analyze single cells fr
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its complexity and grim outlook. Within this disease, M2 macrophages are key players, but their exact role remains a mystery. Researchers decided to dig deeper into how M2 macrophages interact with cancer cells
The human body's blood vessels are incredibly complex. They can suffer from a wide range of diseases. Understanding how these diseases develop is crucial. This is especially true when it comes to the role of immune cells. These cells often cause inflammation, which can lead to serious problems. Whil
Alzheimer's disease, or AD, is a tough nut to crack. It's a brain disorder that slowly chips away at a person's memory and thinking skills. It's tricky because it affects different people in different ways. But here's where things get interesting. Scientists have been using something called single-c
In the world of single-cell research, foundation models like scGPT and Geneformer are making waves. These models are designed to handle complex data without needing extra training. This is known as zero-shot learning. It is crucial to test these models in zero-shot settings. This is because there ar
Microsporidia are tiny, single-celled parasites that can cause infections in people. They are known to target the small intestine. One type of microsporidia, Encephalitozoon intestinalis, is particularly good at infecting humans. These parasites have a sneaky way of hiding inside cells called macrop
Yeast cells, specifically the budding yeast Saccharomyces cerevisiae, are masters of managing amino acids. They use three main pathways to keep amino acid levels in check. The General Amino Acid Control (GAAC) and Target of Rapamycin Complex 1 (TORC1) pathways handle the amino acids inside the cell.
Asthma is a tricky condition that affects millions worldwide. It involves inflammation and narrowing of the airways, making breathing difficult. Scientists have been working hard to understand what causes asthma and how it works. One powerful tool they use is called single-cell RNA sequencing, or sc
