Skin cancer is a big deal. It's the second most common type of skin cancer. It's called cutaneous squamous cell carcinoma or CSCC for short. It's not usually life-threatening, but it can cause serious problems. The tumor's nature varies a lot from person to person. This makes treatment tricky. To understand these tumors better, scientists need to study them in a lab....
Esophageal squamous cell carcinoma is a serious disease. It is a type of cancer that affects the esophagus. It is a tough nut to crack. But, there is hope. Three proteins are making waves in the medical world. They are Trop2, Nectin-4, and PD-L1. These proteins are not your average proteins. They are closely linked to the behavior of cancer cells. They are th...
A new study has shaken up the way doctors might approach tongue cancer. It has uncovered a simple yet powerful tool for predicting how aggressive the cancer might be. The key? The ratio of the tumor's width to the tongue's width. This ratio could help doctors figure out if the cancer has spread to the lymph nodes in the neck. This is a big deal because knowing t...
Oral cancer is a serious issue, and one type, oral squamous cell carcinoma, is quite common. For those who have had surgery and radiation, there is a treatment option called anti-PD1 therapy. This therapy uses the body's immune system to fight cancer. However, not everyone responds well to this treatment. So, researchers looked for ways to predict who might benefit f...
Anal cancer is on the rise, and it's a big problem for gay men who are HIV positive. The number of cases is growing fast, and things might get worse in the near future. These men face a much higher risk of developing anal cancer than the rest of the population. The disease usually starts with a high-risk HPV infection, which can lead to serious cell changes. HPV is v...
In the world of mouth cancer, there is a lot of talk about how cells grow and spread. One interesting player in this game is something called guanylate binding protein 5, or GBP5. This protein has been studied for its role in fighting infections and helping the immune system. But here is where it gets tricky. Its part in cancer, especially in mouth cancer, is not wel...
Scientists have found some interesting things about DNA damage repair genes in people with oral cancer in Pakistan. They looked at five specific genes: TP53, ATR, ATM, CHEK1, and CHEK2. Using advanced tools, they found 42 mutations, with some being completely new. Out of these, 28 were nonsynonymous single nucleotide variations (SNVs). The gene TP53 had the most mut...
These tiny particles, called extracellular vesicles, are everywhere. They are released by cells throughout the body. This can be normal, or it can happen during disease. Even more interesting, these tiny particles can send signals to other cells. They can help start, grow, and spread cancer. One cancer they are known for aiding is a type of cancer in the mouth and t...
A game changing trial changed the health outcome progress for a specific type of esophageal cell carcinoma. One of the major cancerous diseases had to be approached differently. A unique system, this test, had been established to work out how long cancer patients have left to live. Do not think it is a magic trick, which is simply a prediction. For those hav...
Immunotherapy has been making waves in the treatment of esophageal cancer, especially when used after initial chemoradiation. But what about patients with esophageal squamous cell carcinoma who've had a different combo—immunochemotherapy before surgery? Does adjuvant immunotherapy (AIT) still matter for them? That's the question researchers are trying to answer. Ima...