Scientists have taken a big step in understanding a rare condition called coenzyme Q10 deficiency. This condition can cause serious problems, from seizures in babies to movement issues in adults. The cause? Faulty COQ4 genes. Researchers used a technique called CRISPR/Cas9 to tweak stem cells. They created cells with two different COQ4 gene mutations. These cells lo...
Peritoneal dialysis (PD) is a lifeline for many people with kidney failure. But it's not perfect. Over time, it can harm the peritoneal membrane (PM), the lining of the abdomen. This damage can lead to ultrafiltration failure, a serious problem with no current treatment. Scientists have found that peritoneal mesenchymal stem cells (pMSCs) can help prevent this damag...
People die every day because there aren't enough organs for transplants. This is a big problem. Doctors have a new idea to fix this. They want to use special inks and stem cells to print organs with a machine. This could be a game-changer. But it's not that simple. There are lots of questions to answer first. First, is this safe? We don't know yet. The technology is...
NanoTag is a new way to study how DNA and proteins work together. It's a big deal because it skips using IgG, a common tool in older methods. This makes NanoTag more flexible and easier to use. Most methods to study DNA-protein interactions, like ChIP-seq and CUT&Tag, rely on IgG antibodies. These antibodies have to be very specific and high-quality. But not all pro...
The body's defense system against cancer is a complex battlefield. Among the soldiers are CD8+ T cells, which play a crucial role in controlling tumors and responding to immune checkpoint blockade (ICB) therapies. But not all CD8+ T cells are the same. Some are like seasoned veterans, while others are like fresh recruits. Understanding the differences between these c...
Dental pulp stem cells (DPSCs) are a key player in the world of regenerative medicine. They are easy to access and can transform into various cell types. This makes them perfect for creating three-dimensional (3D) models, known as organoids. These organoids are a big deal because they mimic the complexity of real tissues much better than the old flat (2D) cultures. T...
Ankylosing spondylitis is a complex condition. It affects the spine and joints, causing pain and stiffness. It is a chronic disease. It can be tough to manage. Researchers have been looking into how aging might play a role in making this condition worse. They are exploring the connections between aging and the disease. This could lead to new treatments. The focus is...
Breast cancer is a serious issue. It is one of the most common types of cancer in women. It is known for its ability to spread quickly and aggressively. This is due to a specific type of cell called breast cancer stem cells. These cells are particularly troublesome because they can migrate and invade other parts of the body. This makes it hard to treat and cure. ...
Skin cancer is a big deal. It's the second most common type of skin cancer. It's called cutaneous squamous cell carcinoma or CSCC for short. It's not usually life-threatening, but it can cause serious problems. The tumor's nature varies a lot from person to person. This makes treatment tricky. To understand these tumors better, scientists need to study them in a lab....
Ultrasound technology has been a game-changer in the medical field. It is safe and does not require surgery. It has been used to treat long-term illnesses. But did you know that it can also affect fat cells? Researchers looked into how low-intensity pulsed ultrasounds impact fat cells and tissue. They found that a quick burst of ultrasound did not harm or change the ...