Asthma is a widespread respiratory condition that affects people of all ages. It is marked by inflammation that leads to airway problems. The main treatment involves inhaled corticosteroids, but these have their limits. To find better treatments, scientists are looking into the tiny details of how asthma works at the cellular level. In a recent study, researchers cr...
Alzheimer's disease is a big deal. It's a condition where the brain slowly breaks down. It's one of the toughest medical puzzles out there. Scientists have found that certain gene mutations can lead to early-onset Alzheimer's. These mutations are in the presenilin 1 and 2 (PSEN1 and PSEN2) and the amyloid precursor protein (APP) genes. These genes are crucial for the...
The heart's response to injury is complex. One type of cell death, called necroptosis, has caught the eye of researchers. It's different from the more well-known apoptosis. Unlike apoptosis, necroptosis triggers inflammation. This can lead to more damage, scarring, and changes in the heart's structure. The heart can be injured in several ways. One of the most common ...
Alzheimer's disease is a major cause of dementia in older adults. It affects millions of lives worldwide. This condition is linked to how our brain cells communicate and form memories. One key player in this process is something called histone acetylation. This is a process that helps control how our genes are expressed. It is crucial for learning and remembering thi...
Cartilage cancer, also known as chondrosarcoma, is a rare type of cancer. It is difficult to treat. Doctors have limited options for systemic therapy. This means treatments that affect the whole body. To find new ways to fight this disease, researchers took a deep dive. They looked at the molecular and immune landscape of three types of chondrosarcoma. They used a la...
Breast cancer is a big deal, and a lot of it is estrogen receptor-positive (ER+). This means the cancer cells grow when they're exposed to estrogen. Doctors have been fighting this type of cancer for a while, and they've made some good progress. But, there are still some tough cases, like when the cancer spreads or doesn't respond to usual treatments. Scient...
When it comes to colorectal cancer, the immune system is a big player. One type of immune cell, called naïve CD4 T cells, is especially important. These cells are like new recruits in the immune system's army, ready to fight off invaders. But their role in colorectal cancer is not as clear-cut as it seems. First, let's talk about the tumor microenvironment. ...
Neutrophils, which are essential when the body is fighting an infection, are also very important for understanding big health issues like diabetes and heart disease. Most of today's treatments focus on handling metabolism issues. However, the underrated role of inflammation in these diseases often gets overlooked. Systemic inflammation can make these conditions wors...
Triple-negative breast cancer, or TNBC, is a tough and sneaky type of breast cancer that tends to come back even after treatment. This makes finding new ways to fight it super urgent. Biomarkers, special molecules that can help doctors spot cancer and decide on the best treatment, are really important in this battle. Scientists have been digging into some interestin...
Meet Epstein-Barr virus, or EBV for short. This crafty virus is everywhere, silently hanging out in your B cells for your entire life. When your body fights an infection, B cells change how they use energy to stay strong. EBV, being the sneaky bug it is, figures out ways to trick B cells into doing its bidding. It forces B cells to grow and multiply without needing h...