Triple Negative Breast Cancer (TNBC) is a particularly tough type of breast cancer. It doesn't respond to hormones or HER2 treatments. This makes it hard to fight. The disease is known for its rapid growth and resistance to treatment. One key factor in its aggressiveness is the way proteins interact in the tumor environment. Scientists have been looking into the BBO...
Triple-negative breast cancer (TNBC) is a type of breast cancer that lacks three specific receptors. This makes it tricky to treat. However, a recent study has shown some promising results. This study looked into how well a mix of two drugs, docetaxel and cisplatin, work together to fight TNBC. It was a phase II trial, which means it was a small-scale test to see i...
Triple-negative breast cancer is a type of breast cancer that is particularly aggressive. It is known for its fast growth and resistance to many treatments. This cancer relies heavily on a process called glycolysis to fuel its rapid growth. Glycolysis is a way cells turn sugar into energy. In triple-negative breast cancer cells, an enzyme called hexokinase 2 (HK2) pl...
Triple negative breast cancer (TNBC) is a challenging type of breast cancer. It's tough to treat because it doesn't respond well to targeted therapies. This is partly due to changes in certain signaling pathways, like the PI3K and mTOR pathways. Researchers have found that a protein called RICTOR plays a big role. When RICTOR is overactive, it makes TNBC mor...
Breast cancer cells, especially the aggressive triple-negative type, can change when they don't get enough oxygen. This is called hypoxia, and it's a big deal in the world of cancer research. Scientists have found that when these cells are starved of oxygen for a short time, a protein called Annexin A6 (AnxA6) goes down. But if the oxygen deprivation lasts longer tha...
Scientists have found a clever way to make quercetin, a naturally occurring compound, more effective against triple-negative breast cancer (TNBC). They created special liposomes, tiny fat particles, that can target and release quercetin more precisely. These liposomes are coated with a material called NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate, or NPC...
Triple-negative breast cancer, or TNBC, is a tough and sneaky type of breast cancer that tends to come back even after treatment. This makes finding new ways to fight it super urgent. Biomarkers, special molecules that can help doctors spot cancer and decide on the best treatment, are really important in this battle. Scientists have been digging into some interestin...
Adenoid cystic carcinoma is a rare type of breast cancer, making up less than 3. 5% of breast cancer cases. Unlike most breast cancers, it often has a better outlook, even though it falls under triple-negative breast cancer. The first step in managing this cancer is usually breast-conserving surgery. Because it's so uncommon, diagnosing it can be tricky, making it cr...
Triple-negative breast cancer, one of the toughest types to treat, can spread to places like your lungs. Scientists have struggled to understand how this happens until now. They’ve discovered that a process called palmitoylation is to blame. In this process, a molecule named GRK6 gets tagged with fat. This tagged GRK6 starts a chain reaction that involves other prote...