Scientists use a method called hydrogen/deuterium exchange mass spectrometry to study how proteins fold. When comparing two drug versions, they need a test that shows the samples are almost identical, not just different. A new approach called TOST uses two one‑sided tests to set limits of acce
The story of how church and state have clashed goes back more than a thousand years. In the 400s, a pope named Gelasius claimed that while kings ruled on earth, priests had the ultimate say because they promised eternal life. That idea didn’t settle things but it set a pattern that many later leader
The storm is rolling into the western United States, packing up to two feet of snow in high‑elevation areas and throwing strong winds that can create whiteout conditions. The National Weather Service has issued warnings across the Rockies and Pacific Northwest, stressing that the sudden build‑up of
A mining company wants to blast a new granite quarry just six miles from Columbia’s downtown, but locals aren’t welcoming the idea. Heidelberg Materials has asked for permits to dig up 242 acres near Monticello Road, close to colleges and neighborhoods like Haskell Heights. The plan promises to rest
A major crypto platform called Kraken may soon trade on Wall Street. Its leaders have quietly asked regulators for permission to sell shares to the public. This step comes after years of building a bridge between risky digital currencies and regular trading tools. Kraken made big promises when it r
The Cleveland Cavaliers are diving into another playoff run, bringing excitement both on and off the court. Fans can celebrate early at a free tipoff party on E. 6th St. on April 14, from 6 to 8 p. m. The streets will buzz with live music, giveaways, and appearances from team legends and cheer squad
Two popular podcast hosts have been caught in a public disagreement that started quietly but quickly turned into a viral showdown. The issue began when one host’s show was unexpectedly removed from a network, though no clear reason was given. The other host later denied any involvement from the netw
The Berks County Earth Day Festival arrives on April 18, turning Reading City Park into a hub for environmental fun. Instead of starting with the event itself, organizers kick things off at 8 a. m. with a cleanup effort. Volunteers meet at the basketball courts, rolling up sleeves to tidy up the par
President Trump issued a stern warning about Iranian vessels that might approach the U. S. maritime blockade. The threat came as the embargo on ships entering and leaving Iran was set to take effect that day. During a recent war, Trump claimed the U. S. had destroyed Iran’s navy. He noted that only
The Middle East felt a chill when the United States and Iran could not reach an agreement after more than 20 hours of discussion in Islamabad. U. S. Vice President J. D. Vance admitted that the differences between the two sides were too wide to bridge at this time, leaving a fragile ceasefire in dou
