Gold nanoclusters combined with alpha-lipoic acid, or FANCs, are gaining attention in the medical field. These tiny particles have shown potential for creating new drugs. But here is the thing: while short-term tests on mice showed no immediate harm, the long-term effects remained a mystery. Researchers decided to dive deeper. They focused on what happens when t...
Melanoma is a type of skin cancer that has seen huge improvements in treatment over the past few years. This has led to better outcomes and quality of life for patients. Doctors can now tell the difference between melanomas caused by long-term sun exposure and other types. This is thanks to advances in genetic testing. Kids are not immune to melanoma. In fact, it is...
Imagine a tiny protein called MALT1. It's like a key player in a game of cancer survival. This protein is part of a group of enzymes called cysteine proteases. It's unique because it's the only paracaspase in humans. This means it has a special role in helping certain types of cancer cells stay alive and grow. These cancers are driven by a pathway called NF-κB. Two t...
Imagine a tiny molecule that can stop cancer in its tracks. That's what scientists are hoping for with thienopyrimidine. This special ring-shaped molecule is like a key that can unlock cancer cells' defenses. It does this by targeting something called protein kinases. These are like the bosses of cancer cells, telling them when to grow and spread. By blocking these b...
In recent years, the biopharmaceutical industry has seen a significant shift. Chinese companies are now at the forefront of developing innovative drugs. This trend has caught the attention of U. S. pharmaceutical giants, who are increasingly looking to China for promising new treatments. One notable example is the experimental cancer drug developed by a Chinese comp...
Imagine if there were drugs that could tackle brain diseases in a whole new way. Brain diseases like Parkinson's and Alzheimer's are tough. They cause brain cells to die. Most drugs out there just treat the symptoms. They don't fix the root cause. This is where hybrid drugs come in. These are special drugs made by combining different medicines into one. They can hit ...
At first glance, tau and CPEB3 might seem like an unlikely duo. Tau is a protein that can go rogue and form harmful clumps in Alzheimer's disease. On the other hand, CPEB3 is essential for long-term memory and forms functional clumps to do its job. So, what happens when these two memory-related proteins get together, you ask? Scientists have been exploring t...
Xtalpi, a Hong Kong-listed company, is making waves in the tech world. It started with a bang in 2016. Wen Shuhao, the company's cofounder and chairman, and his team participated in a blind test. The challenge was to predict the 3D structure of molecules. These molecules show how effective a drug can be. Wen's team used AI and quantum physics-based calculations. The ...
Liver problems caused by drugs are a big deal. They can lead to sudden liver failure, and they often show up only after a long time of taking the drug. This is a huge problem for people who make new drugs. They have to stop their work because it's too risky. But there is new hope. Scientists are using advanced liver models and AI. These two things combined can pred...
In a significant development, the U. S. Food and Drug Administration (FDA) has given the green light to a new non-opioid painkiller. Called Journavx. This new medicine is a big deal because it's the first of its kind to target pain signals in the peripheral nervous system. This means it stops pain before it even reaches the brain. We all know, pain is a big part of ...