Proteins are like tiny machines in our bodies. They do lots of important jobs. But before they can work, they need to fold into the right shape. This is called the native structure. Scientists know a lot about these final shapes. But they don't know much about the shapes proteins take while folding.
CapG, a key enzyme from Staphylococcus aureus, folds and unfolds in a complex dance. This protein, which helps the bacteria build its defence shield, changes shape based on its concentration and surroundings. Scientists studied a replica of CapG, called rCapG, and found it can exist in many forms, f
Engrailed homeodomain, or EngHD, is a crucial protein that controls over 200 genes by acting as a transcription factor. It folds quickly, but scientists aren't quite sure how electrostatic interactions within it affect its stability and cooperativity during folding. Recent research used a computer m
This week, AI has made a significant impact on the Nobel Prizes. John Hopfield and Geoffrey Hinton won the Nobel Prize in Physics for their groundbreaking work in machine learning, which laid the foundation for today’s AI. Just yesterday, Demis Hassabis and John Jumper of Google DeepMind, along with
