THERAPY

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Jan 02 2025HEALTH

Rethinking Recurrence: PIK3CA Mutations in HR+, HER2- Breast Cancer

Early-stage breast cancer patients with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) tumors face a big challenge: disease recurrence. This kind of cancer is diverse and tricky to manage because a quarter of these patients will see their disease come b

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Jan 02 2025HEALTH

Boosting Immunotherapy After Neoadjuvant Treatment for Esophageal Cancer: A Closer Look

Immunotherapy has been making waves in the treatment of esophageal cancer, especially when used after initial chemoradiation. But what about patients with esophageal squamous cell carcinoma who've had a different combo—immunochemotherapy before surgery? Does adjuvant immunotherapy (AIT) still matter

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Jan 01 2025HEALTH

Uncovering the Hidden Benefits of Regularly Visiting a Physical Therapist

Physical therapy isn't just for recovery after surgery or injury. It's also about prevention and maintaining good health. Sharon Dunn, a former president of the American Physical Therapy Association, says it's "the best-kept secret in health care. " Many people think physical therapists only help y

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Jan 01 2025HEALTH

How Letters Help in Group Therapy Sessions

Ever imagined using letters to heal? That’s exactly what happens in group schema therapy. This type of therapy mixes ideas from different fields to help patients in a unique way. One of the cool tools they use is therapeutic letters. You might think, “What can a letter do for therapy? ” Well, these

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Dec 31 2024HEALTH

Tislelizumab and Chemo: A Cost-Effective Pair for Advanced Stomach Cancer in China

Imagine you're a healthcare provider in China, trying to figure out the best treatment for advanced stomach cancer. A recent study, RATIONALE-305, found that combining a drug called tislelizumab with chemo works better than chemo alone. Now, researchers wanted to know if this combo is worth the extr

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Dec 31 2024SCIENCE

Discovering Methotrexate's Role in Lung Cancer Treatment

MicroRNAs, or miRNAs, are tiny molecules that can greatly influence how cancer cells grow. Out of all these miRNAs, miR-20b is particularly interesting because it's often out of balance in lung cancer. Scientists used a special computer program to search for small molecules that could tame miR-20b.

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Dec 31 2024SCIENCE

The Hidden Power of Oridonin: A New Player in Cancer Drug Design

Scientists have found a clever way to turn a natural compound into a tool for fighting cancer. This compound, called Oridonin, can help in the design of new drugs called PROTACs. PROTACs are like tiny agents that can hunt and destroy specific proteins in cancer cells. So, what makes Oridonin specia

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Dec 30 2024HEALTH

Are More Statins Necessary After Moderate Dose Success?

Many health guidelines advise specific low-density lipoprotein cholesterol (LDL-C) targets and strong lipid-lowering therapy (LLT) for patients at high risk. But what happens when these targets are met using moderate-intensity statins? Do physicians need to increase LLT further? We explored this que

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Dec 30 2024HEALTH

Boosting Knee Recovery: Early Rehab and Brain Stimulation

You've probably heard that early rehabilitation is key after a sports knee injury. But what if we added something extra to the mix? Let's talk about combining early rehab with a special brain treatment called repetitive transcranial magnetic stimulation (rTMS). Researchers wanted to see if this com

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Dec 30 2024HEALTH

Fish Extracts in Cancer Treatment: A Closer Look

Febrile neutropenia, a severe complication for patients with blood cancers undergoing chemotherapy, is a major concern. This study explored whether Channa striata, a freshwater fish, could help. The goal was to see if extracts from this fish could boost the body's neutrophil count and function, and

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