How THC Makes You Feel High: A Neuroscience Lesson

Ever wondered how cannabis makes you feel "high"? Let's dive into the science behind it. Your body naturally produces cannabinoids, similar to what's found in marijuana. One of these, called anandamide, acts as a neurotransmitter, sending messages between nerve cells. These messages impact areas of the brain linked to pleasure, memory, and coordination. THC, the active ingredient in cannabis, can bind to these same cannabinoid receptors on neurons. This interaction changes various mental and physical functions. The endocannabinoid system, which uses these neurotransmitters, is crucial for the nervous system's normal operation. THC affects specific brain areas, like the hippocampus and orbitofrontal cortex, which help with memory formation and attention shifting. It also triggers the release of dopamine, a signaling chemical, in the reward system. This dopamine rush contributes to the enjoyable "high" that marijuana users experience.