Lifestyle Habits and Healthy Aging in Cystic Fibrosis Patients: What We Know and Where We Need to Go

People living with cystic fibrosis have seen remarkable improvements in survival rates over recent decades, largely thanks to breakthroughs like CFTR modulator therapies introduced around 2019. These treatments, especially the combination of elexacaftor, tezacaftor, and ivacaftor, have significantly extended life expectancy for individuals with the condition. Yet, living longer with cystic fibrosis brings its own set of challenges. Residual CFTR dysfunction, ongoing inflammation, new health complications, complicated treatment routines, and emotional struggles all take a toll on a person's ability to age well. Researchers now define healthy aging in this population as supporting physical and mental well-being so people can stay independent and self-sufficient for as long as possible. Stress, diet, exercise, sleep quality, and sticking to tre

atment plans all play important roles in shaping health outcomes for these patients. Studies in the general population already show that lifestyle habits meaningfully influence well-being, and researchers believe similar principles should apply to people with cystic fibrosis. The challenge is figuring out which specific behaviors matter most and how to test them effectively in this unique patient group. As science moves closer to potential curative approaches, understanding how daily habits can support healthy aging becomes even more critical. This review examines what is currently known about lifestyle factors affecting adults with cystic fibrosis, pinpoints where knowledge gaps remain, and suggests promising directions for future research aimed at improving quality of life and functional independence through behavior-focused interventions.

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