Exercise has long been known to benefit the brain, especially in those with Alzheimer's disease. But how exactly does it work? Recent studies have shed some light on this mystery. They found that physical activity can change how certain brain cells work. These changes might help protect memory.

The brain has many types of cells, and exercise seems to affect two types in particular. One is microglia, which are like the brain's cleanup crew. The other is a type of astrocyte that hangs out near blood vessels. These astrocytes were only recently discovered. Both of these cell types showed changes in their gene activity after exercise. This could mean they play a role in keeping the brain healthy.

One gene, called Atpif1, stood out as a key player. It seems to help create new neurons. This is important because Alzheimer's disease often leads to the loss of neurons. So, finding ways to boost neuron growth could be a big deal.

To make sure these findings apply to humans, researchers looked at brain tissue from people with Alzheimer's. They found similar patterns, which is a good sign. This means that what they saw in mice might also happen in people.

The hippocampus is a part of the brain crucial for memory and learning. It's one of the first areas affected by Alzheimer's. The study focused on this region, using a technique called single-nuclei RNA sequencing. This allows scientists to look at how genes are active in individual brain cells. It's like having a super-powered microscope that can see tiny details.

The researchers used mice that are often studied for Alzheimer's because they show similar symptoms to humans. They gave these mice running wheels and found that exercise improved their memory. Then, they looked at the gene activity in thousands of brain cells. They saw changes in both microglia and the newly discovered astrocytes.

The study also found that exercise can help restore some of the gene activity that goes haywire in Alzheimer's. This is promising because it suggests that exercise might be able to reverse some of the damage caused by the disease.

The findings could lead to new treatments for Alzheimer's. By targeting specific brain cells, scientists might be able to develop drugs that mimic the benefits of exercise. This could be a game-changer for people with Alzheimer's.

BRAIN CELL ACTIVITY

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