In the fight against cancer, scientists are always looking for new ways to make treatments work better. One big challenge is that cancer cells can become resistant to drugs over time. To tackle this, researchers have come up with a clever idea: combining two powerful tools to attack cancer cells from different angles. First, they created a special drug called a circ...

DLBCL is a type of blood cancer that can be tough to treat. It stands for diffuse large B-cell lymphoma. The introduction of CAR-T therapy has been a game-changer for patients with relapsed or refractory DLBCL. CAR-T therapy is a type of treatment that uses a patient's own immune cells to fight cancer. It was first approved by the FDA in 2017. But how has this ne...

Multiple myeloma (MM) is a type of cancer that affects plasma cells. It can be treated with CAR-T cell therapy, which uses engineered T cells to target and kill cancer cells. However, relapse can happen. The relapse can occur even after a long period of remission. This is a big problem. It can happen because the cancer cells change and become resistant to the treatme...

At a single hospital, patients with large B-cell lymphoma (LBCL) who didn't respond to initial treatments were given either lisocabtagene maraleucel (liso-cel) or axicabtagene ciloleucel (axi-cel). Liso-cel is newer and not widely studied outside clinical trials yet. From June 2021 to September 2022, 50 patients got axi-cel and 37 got liso-cel. Those who received lis...