The use of far-ultraviolet C (Far-UVC) light, specifically within the 200 to 235 nanometer range, has shown promise in killing germs. This type of light is being explored for various medical uses. However, its effectiveness against infections deep within the body, such as those in the lungs, is still being studied. The safety of Far-UVC light on different human tissues is also a major concern.

Researchers conducted experiments using a krypton-chloride excimer lamp and a pulsed laser system. They wanted to see how Far-UVC light affects human lung cells and tracheal tissue. The study exposed these tissues to different doses of continuous wave and pulsed Far-UVC light. The results showed that even low doses of Far-UVC light can cause significant damage to lung cells.

The damage included the formation of harmful DNA structures and cell death. Specifically, the light caused DNA double-strand breaks and the formation of pyrimidine-pyrimidone (6-4) photoproducts. These changes led to a reduction in cell viability and an increase in cell death markers. The findings suggest that while Far-UVC light has potential benefits, it also poses risks to lung health.

The study highlights the need for further research. Understanding the full impact of Far-UVC light on human tissues is crucial. This knowledge will help in developing safe and effective medical applications. It is important to balance the benefits of Far-UVC light with its potential risks. This way, it can be used to improve health outcomes without causing harm.

DNA DAMAGE RESEARCH

Far-UVC Light: Double-Edged Sword for Lung Health

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