Scientists used computer models that predict how proteins fold together with potential drug molecules. They focused on LSD1, an enzyme that changes how DNA is read by removing methyl groups from histones. Because LSD1 also serves as a scaffold for other proteins, blocking it could treat diseas
The quest for new medicines is a marathon, not a sprint. It is a costly and time-consuming process with a high failure rate. Scientists are always on the hunt for new methods to make drug discovery more efficient. One promising approach is de novo drug design. This method has gained traction in the
The fight against COVID-19 is far from over. New variants of the virus keep popping up, making it tough for existing treatments to keep up. Vaccines are great, but they aren't enough on their own. We need new drugs that can adapt to these ever-changing viruses. One promising approach is to target th
Inflammation is a big deal, and it's involved in many diseases that affect people worldwide. One specific receptor, called P2Y14, plays a crucial role in these inflammatory responses. Scientists have been working on new drugs to block this receptor and reduce inflammation. They used a process called
Caspase-6, a protein linked to brain cell death and neurodegeneration, has been on scientists’ radar for a while. This protein is especially active during inflammation and may play a role in the early stages of Alzheimer's disease. Researchers have now combined two drug-designing approaches to find
Antimicrobial Resistance (AMR) is a big problem worldwide. Microbes like bacteria, fungi, and viruses are becoming tougher to kill with our usual medicines. Multidrug Resistance (MDR) happens when these bugs fight back against several drugs at once. The World Health Organization has highlighted the
