Drugs are designed to heal, but sometimes, they can harm. This is especially true when it comes to idiosyncratic drug-induced liver injury, or iDILI. This condition is tricky. It does not affect everyone who takes a certain medication. It is unpredictable. It can cause serious health problems. It can even stop a promising drug from ever reaching patients. The liver ...
The battle against COVID-19 has led to some clever tricks. One such trick is a new way to watch a key protein in the virus. This protein is called Mpro. It is super important for the virus to make copies of itself. Because it is so important, scientists are always on the lookout for ways to stop it. This is where the new trick comes in. It uses something called phyco...
Drug development has always been a complex process. It involves improving the way drugs work and how they behave in the body. One exciting area of research is co-crystal technology. This method is eco-friendly, simple, and effective. It offers a new way to enhance the properties of drugs. A recent study focused on creating a co-crystal using three compounds: nitrofu...
Parkinson's disease is a tough condition to manage. It's not just about the shaking and movement issues. Many people with Parkinson's also struggle with depression. This is a big problem, and scientists are always looking for better ways to help. One interesting area of research is the kynurenine pathway. This is a complex process in the body that involves the break...
Gold nanoclusters combined with alpha-lipoic acid, or FANCs, are gaining attention in the medical field. These tiny particles have shown potential for creating new drugs. But here is the thing: while short-term tests on mice showed no immediate harm, the long-term effects remained a mystery. Researchers decided to dive deeper. They focused on what happens when t...
Melanoma is a type of skin cancer that has seen huge improvements in treatment over the past few years. This has led to better outcomes and quality of life for patients. Doctors can now tell the difference between melanomas caused by long-term sun exposure and other types. This is thanks to advances in genetic testing. Kids are not immune to melanoma. In fact, it is...
Imagine a tiny protein called MALT1. It's like a key player in a game of cancer survival. This protein is part of a group of enzymes called cysteine proteases. It's unique because it's the only paracaspase in humans. This means it has a special role in helping certain types of cancer cells stay alive and grow. These cancers are driven by a pathway called NF-κB. Two t...
Imagine a tiny molecule that can stop cancer in its tracks. That's what scientists are hoping for with thienopyrimidine. This special ring-shaped molecule is like a key that can unlock cancer cells' defenses. It does this by targeting something called protein kinases. These are like the bosses of cancer cells, telling them when to grow and spread. By blocking these b...
In recent years, the biopharmaceutical industry has seen a significant shift. Chinese companies are now at the forefront of developing innovative drugs. This trend has caught the attention of U. S. pharmaceutical giants, who are increasingly looking to China for promising new treatments. One notable example is the experimental cancer drug developed by a Chinese comp...
Imagine if there were drugs that could tackle brain diseases in a whole new way. Brain diseases like Parkinson's and Alzheimer's are tough. They cause brain cells to die. Most drugs out there just treat the symptoms. They don't fix the root cause. This is where hybrid drugs come in. These are special drugs made by combining different medicines into one. They can hit ...