Ever wondered why garlic is such a superfood? Deep inside its bulbs lies a powerful compound called Allicin. Scientists have discovered that Allicin can protect skin cells from sun damage, specifically from UVB rays. They tested this on a type of skin cell called keratinocytes, using the HaCaT cell line. These cells were exposed to UVB light to mimic sun damage. Allicin was added to some of these cells before they were exposed to UVB, and it showed some impressive results.

The cells that got a dose of Allicin before UVB exposure had better survival rates and less cell death. Allicin also helped reduce the levels of harmful molecules like TNF-α, IL-6, and IL-1β, which are involved in inflammation. It's like Allicin was there to calm down the cells after they got sunburned.

Moreover, Allicin seemed to boost the cells' defense system. It lowered the amount of harmful oxygen molecules (ROS) and reduced signs of oxidative stress. It did this by increasing the levels of antioxidant proteins like SOD, CAT, and GSh-Px. It's like Allicin was giving these cells a protective shield.

Interestingly, Allicin also influenced a process called autophagy, which is the cells' way of recycling old parts. Allicin reduced autophagy and changed the expression of proteins like Beclin-1 and p62. This is important because too much autophagy can be bad for cells under stress.

Finally, Allicin messed with something called NLRP3 inflammasomes, which are involved in inflammation. It basically told them to calm down, reducing proteins like Caspase-1. At the same time, it activated a pathway called PI3K/Akt, which helps cells survive and grow.

So, the next time you think about garlic, remember it might have a secret weapon against sun damage.

KERATINOCYTES

Garlic's Secret Weapon: Allicin Fights Sun Damage

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