Multiple myeloma is a tough cancer to treat. It's a disease that affects plasma cells and, despite many treatments, it's still not curable. Scientists are always looking for new ways to fight it. Recently, they tested a bunch of small-molecule inhibitors to see which ones could stop the growth of myeloma cells. Out of 216 options, enitociclib stood out. It's a specia...
Multiple myeloma is a type of blood cancer. It is a serious condition that affects plasma cells. Doctors in Germany face a tough job when treating patients whose myeloma has come back or is not responding to treatment. This is known as relapsed and/or refractory multiple myeloma (RRMM). They have to pick the best treatment plan for each patient. This is not an e...
The Gulf region is grappling with a rise in multiple myeloma cases, a blood cancer that affects plasma cells. This region includes countries like the United Arab Emirates, Qatar, Bahrain, Kuwait, and Oman. These nations have seen significant economic growth, but their healthcare systems still face hurdles. The average age of diagnosis in the Gulf is surprisingly low...
Multiple myeloma is a formidable disease. Even with advanced treatments like CAR T-cell therapy, patients often experience a return of the disease. This is a huge problem. Scientists have been investigating why this happens. They looked at 10 patients who relapsed after receiving GPRC5D CAR T-cell therapy. They found that eight out of ten patients had lost the GPRC5...
Scientists have been puzzling over a unique type of immune cell called CD20+ T-cells. These cells were first spotted in the bloodstream and later found hiding in the bone marrow of people with certain blood cancers and immune disorders. CD20+ T-cells are particularly interesting because they show up in people with two specific conditions: monoclonal gammopathy o...
Multiple myeloma (MM) is a type of cancer that affects plasma cells. It can be treated with CAR-T cell therapy, which uses engineered T cells to target and kill cancer cells. However, relapse can happen. The relapse can occur even after a long period of remission. This is a big problem. It can happen because the cancer cells change and become resistant to the treatme...
CAR-T cell therapy has opened up a new pathway for treating multiple myeloma. In Australia, doctors are now using this cutting-edge treatment. This involves a lot of complex decision-making. These decisions are critical for managing patients. The goal is to find the best practices for using CAR-T cell therapy in multiple myeloma. The relevant bodies have...
Patients with multiple myeloma (MM) often face infections due to their weakened immune system and the treatments they receive. One rare but serious infection is Cryptococcus, a fungus that can cause pneumonia and spread to the brain. Here's a look at a patient's experience with this infection. A 75-year-old man was being treated for relapsed MM. Doctors found lung i...
In Japan, doctors kept an eye on how well isatuximab plus pomalidomide and dexamethasone (Isa-Pd) worked for people with relapsed or refractory multiple myeloma (RRMM) who were frail. They collected data from patients treated between October 2020 and October 2021, following them for up to a year. Out of the total, 40 people were frail, 29 were fit or intermediate, an...
Scientists have made a significant discovery in the fight against cancer. They've created new compounds that can destroy specific forms of a protein called NSD2, which plays a role in cancer development. NSD2 comes in three versions due to a process called alternative splicing: long, short, and RE-IIBP. Previously, researchers could only target the long and short ver...