The world of bacteria is full of surprises. Take avian pathogenic Escherichia coli (APEC), for example. These bacteria have clever ways to make birds sick. One of their tricks involves a protein called hemolysin co-regulatory protein (Hcp). This protein is part of a system that helps bacteria attack host cells. Researchers have been curious about how Hcp works, espec...
Wag31 is a key player in the world of mycobacteria, specifically in managing how these bacteria grow and maintain their shape. This protein has two main parts: an N-terminal DivIVA-domain and a C-terminal coiled-coil domain. These parts work together to keep the bacteria's cell shape in check and direct how the cell grows and stretches. The N-terminal DivIVA-domain ...
The world inside a cell is complex. It is filled with tiny parts called RNA and proteins. These parts work together in ways that are crucial for life. Scientists have long wanted to understand how these parts interact. This is not easy. Traditional methods often use a process called crosslinking. This can change the natural state of the cell and give false results. ...
Diaryl ureas (DU) are like the superheroes of medicinal chemistry. They have a special structure that makes them super useful in treating diseases. They can do more than just stop cancer cells from growing. They can also change how genes are read, mess with how cells grow, and calm down inflammation. But how do they do all this? It's all about how they connect with p...
In the world of science, finding new ways to control how proteins interact can be a game-changer. Proteins are like tiny workers in our cells, and they often need to team up to get things done. These team-ups, or protein-protein interactions (PPIs), are super important for many things happening inside our bodies. Scientists are always on the hunt for new drugs that c...
Proteins are like tiny workers in our bodies, and they often team up to get things done. These partnerships, called protein-protein interactions (PPIs), are crucial for many important jobs, like telling cells when to grow or fixing damaged DNA. When these interactions go wrong, they can cause diseases, including cancer. Scientists are now exploring a new way to fight...
Ever wondered why some tiny peptides can pack a big punch when it comes to treating diseases? These little protein chunks could be the next big thing in medicine. But finding the right ones isn't easy. Scientists have a tough time predicting how peptides will interact with proteins in our bodies. This is where a clever tool called TPepPro comes in. It uses deep learn...