Oral cancer is a big deal, especially in Asia, where it's a leading cause of cancer deaths. It is important to understand the factors that influence how oral cancer cells behave. One such factor is the stiffness of the tumor's environment. This stiffness can change how cancer cells move, grow, and spread. It is important to understand how this stiffness affects o...
In the fight against breast cancer, a new approach is gaining attention. It involves tiny, smart particles that can target and attack tumors in multiple ways. These particles are designed to overcome two big challenges: low oxygen levels in tumors and high levels of a substance called glutathione. This substance protects cancer cells from damage. The new strategy use...
Lactate is not just a waste product from sugar breakdown. It is a key player in cancer's strategy. It fuels cells, sends signals, and helps cancer cells talk to each other. This is a big shift from the old idea of lactate. It shows that lactate can move around and affect different cells, tissues, and organs. This is crucial to understand because cancer cells produce ...
Cancer treatment has seen a big change with the introduction of neoadjuvant immunotherapy. This approach is used before surgery or other main treatments. It has shown promise in fighting several types of cancer, like melanoma, lung, bladder, colorectal, and breast cancer. The idea is to boost the body's own defenses to attack cancer cells early on. But, there are hu...
Cancer is deadly because it spreads to other parts of the body. This spreading, or metastasis, happens when cancer cells leave the original tumor and travel through the bloodstream to form new tumors elsewhere. But, this journey is tough. Most cancer cells don't survive the trip. They have to squeeze into tiny blood vessels, stick to the vessel walls, and squeeze out...
Breast cancer cells, especially the aggressive triple-negative type, can change when they don't get enough oxygen. This is called hypoxia, and it's a big deal in the world of cancer research. Scientists have found that when these cells are starved of oxygen for a short time, a protein called Annexin A6 (AnxA6) goes down. But if the oxygen deprivation lasts longer tha...
GI cancers, which include tumors in the stomach, intestines, and other parts of the digestive system, are a major cause of cancer deaths worldwide. Once these cancers reach an advanced stage, survival rates drop significantly. This is where immunotherapy comes into play. Immunotherapy has shown promise in extending the lives of patients with late-stage GI cancers. Ho...
First, let's talk about the tumor microenvironment, or TME. It's a tough place for treatments to work. Hypoxia, or low oxygen levels, and high levels of glutathione (GSH) make it hard for photodynamic therapy (PDT) to do its job. Scientists have been working on a way to turn these challenges into advantages. They created a new molecule called Ir-Fc. This molecule is ...
Imagine you're trying to understand how your body's immune system affects liver cancer. It's a complex puzzle, right? Researchers have been studying the tiny immune cells that live near liver tumors. These cells play a big role in how cancer grows and how well treatments work. Scientists looked at a bunch of liver cancer samples from different databases and real-lif...
Imagine a tiny, smart bomb designed to wipe out cancer cells and wake up the body’s immune system to fight back. This is the idea behind a new nanogel drug delivery system, DPCLG. It’s like a sneaky military operation, targeting two types of cells in the tumor’s neighborhood: cancer cells and immune cells that have been fooled into helping the tumor grow. First, the...