Proteins are like tiny workers in our body, and they often need a bit of a tweak to do their jobs right. One such tweak is called SUMOylation. It's like adding a small tag to a protein, which can change how it works, where it hangs out in the cell, or even how long it sticks around. This tagging pr
Cancer is a tricky foe, always finding ways to dodge treatments. One type, Ewing sarcoma, often affects young people. It's caused by a gene fusion called EWS::FLI1. This fusion acts like a commander, driving cancer cells to multiply uncontrollably. Scientists made a surprising find. EWS::FLI1 disru
Parasitic worms, or nematodes, cause a lot of trouble. They bring on various diseases in animals and even in humans. The drugs used to fight these pests, known as anthelmintics, are becoming less effective. This is due to the worms developing resistance to these treatments. So, finding new ways to t
Axl is a key player in the TAM family of receptor tyrosine kinases. It plays a significant role in promoting cancer growth and immune system evasion. It also contributes to resistance against various cancer treatments. This makes Axl a hot target for new cancer therapies. Axl's role in cancer is c
Lactate is not just a waste product from sugar breakdown. It is a key player in cancer's strategy. It fuels cells, sends signals, and helps cancer cells talk to each other. This is a big shift from the old idea of lactate. It shows that lactate can move around and affect different cells, tissues, an
Melanoma, a type of skin cancer, often becomes resistant to treatment. This resistance can be due to chemotherapy-induced senescence. This means that instead of dying, some cancer cells stop growing but do not die. This can lead to treatment failure. Finding and targeting these senescent cells is a
Gonorrhea, a common sexually transmitted infection, is a growing concern. It is becoming increasingly resistant to treatment. The ability to monitor this trend in the United States has just been halted. This is due to the recent layoffs of 77 scientists. These experts were responsible for collec
HIV is a big problem in Honghe Prefecture, Yunnan Province, China. With so many people infected, it is important to understand how the virus spreads. This helps in stopping the spread. A recent study looked at 1004 new HIV cases in 2022. The goal was to figure out how the virus is transmitted and to
Bacteria are becoming resistant to antibiotics, making infections harder to treat. Scientists are exploring new ways to fight these superbugs. One promising idea is using tiny, artificial enzymes called nanozymes. These nanozymes mimic natural enzymes in our bodies. They can generate reactive oxygen
Lung cancer is a massive problem worldwide. It is a leading cause of death. NSCLC, or non-small cell lung cancer, makes up a huge portion of these cases. Most people find out they have it when it is too late. This makes it hard to treat. The good news is, there might be a new way to fight it.
