Neutrophils, which are essential when the body is fighting an infection, are also very important for understanding big health issues like diabetes and heart disease. Most of today's treatments focus on handling metabolism issues. However, the underrated role of inflammation in these diseases often gets overlooked. Systemic inflammation can make these conditions wors...
When cancer spreads, it tends to twist the environment around it. In metastatic epithelial ovarian cancer (EOC), normal neutrophils, which usually help fight infections, get tricked into becoming "suppressors. " These reprogrammed neutrophils can hinder the activation of T cells, a vital part of our immune system. This study set out to investigate if certain markers ...
Ever wondered how cancer cells trick the immune system into turning a blind eye? Well, there's an enzyme called Deltex E3 ubiquitin ligase 2, or DTX2, that does just that in liver cancer. Scientists found out that this enzyme helps cancer cells in the liver attract certain immune cells called neutrophils, which then act as shields for the cancer cells. These neutroph...
In the fight against pneumonia, airway epithelial cells (AECs) play a crucial part. One protein they produce, called Sectm1a, catches our attention. Researchers found that Sectm1a is triggered by a specific type of immune signal, called type I interferons (IFNs), during the early stage of a lung infection caused by Streptococcus pneumoniae. They studied this in mice ...