The quest for new medicines is a marathon, not a sprint. It is a costly and time-consuming process with a high failure rate. Scientists are always on the hunt for new methods to make drug discovery more efficient. One promising approach is de novo drug design. This method has gained traction in the
Cancer is a major health issue worldwide, largely due to the rapid spread of abnormal cells. These cells often form tumors, like carcinomas, which come from epithelial cells growing out of control. Tumors release growth factors such as FGF and VEGF. These factors help new blood vessels form, a proce
Azetidines are small molecules that are very useful in making medicines. Scientists have found a new way to create these molecules using light and chemicals that flow. This method is quite flexible. It can make tiny amounts, like milligrams, or large amounts, like multigrams, of azetidines. The proc
The field of medicine is excited about a new approach to treating diseases. This method involves breaking down harmful proteins rather than just stopping them from working. This is a big deal because it can tackle proteins that were once thought to be impossible to target. This approach is called PR
Osteoarthritis is a widespread condition that affects many people. Unfortunately, there are few effective treatments besides surgery. This is where molecular docking comes in. It's a technique used in drug discovery to find new compounds that can treat diseases. Until now, it hasn't been used to fin
Fungi are amazing. They make all sorts of useful stuff. These compounds are like nature's medicine cabinet, full of potent ingredients. Scientists have been digging into marine fungi because they make some of the strongest compounds out there. One such fungus is Penicillium rubens YAP001. It was fou
Inflammation is a tricky thing. It's like a double-edged sword. It helps the body fight infections and heal injuries, but it can also cause problems when it goes into overdrive. This is where natural products come in. Some plants have special compounds that can calm down inflammation. These compound
In the world of medicine, a huge milestone was reached in 2024. It was the 15th birthday of ChEMBL. It is a big deal because ChEMBL is a massive, free-to-use database. It is like a giant library filled with information about drugs and how they work. This library is hosted by the European Bioinfor
Picture this: scientists are on a hunt for new drugs, but the targets are always changing. They need to figure out how molecules will act in the body, like if they're harmful or can cross the blood-brain barrier. This is where AI steps in, speeding up and improving the process. AI, especial
In the world of science, finding new ways to control how proteins interact can be a game-changer. Proteins are like tiny workers in our cells, and they often need to team up to get things done. These team-ups, or protein-protein interactions (PPIs), are super important for many things happening insi
