Our bones might feel far stronger than what they may really be; Rust-like things called reactive oxygen species(Ways to describe them can vary. We've heard of free radicals as an example) could possibly damage them over long stretches of time. This science term for "arthritic degeneration. “ In a fresh twist on an ageing problem. During several tests done on cell c...
Alzheimer's disease (AD) can be quite tricky, with various processes happening behind the scenes in our brains. One of these is ferroptosis, a type of cell death involving iron and oxidative stress. As we age, our body's antioxidant systems may not work as well, leading to more ferroptosis. This can make AD symptoms worse. A key player here is Nrf2, a protein that h...
Ferroptosis is a type of cell death that cancer cells often avoid, but the reasons behind this in certain cancers driven by the KRAS oncogene are not well understood. Scientists have found that lactate dehydrogenase B (LDHB), a protein involved in energy production, helps KRAS-driven lung cancer cells escape ferroptosis. Unlike its closely related form, LDHA, LDHB ha...
Ever pondered what happens when cells die? Scientists have discovered a fascinating tool to observe this process. Introducing TJ-FRP, a unique dye that lights up when cells face trouble. Picture it like a tiny beacon inside our bodies, especially handy for watching mitochondria, the little power plants within cells. Cells use a process called ferroptosis to die. Dur...
Ever wonder how some cells in your body can make you sick? Let’s talk about interleukin-17D (IL-17D). This tiny protein has been found in higher amounts in people with clogged arteries, known as atherosclerosis. Researchers decided to dig deeper into what IL-17D does in our bodies. They found that it triggers a type of cell death called ferroptosis in endothelial cel...
Imagine having a tiny, smart tool that can target cancer cells with precision and efficiency. That's what porphyrin-based nanoscale metal-organic frameworks (MOFs) are doing in the world of cancer treatment. These tiny structures are like superheroes, combining the powers of photodynamic therapy and ferroptosis to fight cancer cells. Photodynamic therapy is ...