Lung cancer is a tough opponent, especially when it spreads to the brain. The blood-brain barrier, a protective shield, often stops treatments from reaching brain tumors. Osimertinib, a drug used to treat a specific type of lung cancer, can cross this barrier. However, some cancer cells develop resistance to it. This is where a new player, compound D18, steps in. D1...
Scientists have found a protein that might help spot aggressive cancers early. This protein, called SAS-6, helps cells get ready to divide. But it also seems to play a role in how cancer spreads. Researchers from Brunel University of London discovered that high levels of SAS-6 make cells grow more and longer cilia. These are tiny antennae on cells that sense their su...
In parts of the world where it's common, a virus called Epstein-Barr (EBV) is found in over 90% of people with a specific type of throat cancer. This virus, the first known human DNA tumor virus, can cause big changes in how our chromosomes are organized. When EBV interacts with human DNA, it can rearrange the 3D structure of chromosomes. This can lead to what scient...
Lung cancer is a major killer, claiming many lives each year. One of the scariest things that can happen is when lung cancer spreads to the brain. This is called brain metastasis, or BM for short. It's a big problem for people with a type of lung cancer called non-small cell lung cancer, or NSCLC. BM makes life really hard for patients and their families. It's tough ...
Lung cancer is more likely to spread to the brain than breast cancer or melanoma. This is a big problem because the blood-brain barrier makes it hard for treatments to reach the brain. Researchers wanted to find out which cancer spreads to the brain the most and if a natural compound could stop it. They used different cancer cells to create brain metastasis models. ...
Triple-negative breast cancer (TNBC) is tough to treat. It doesn't respond well to common therapies. But why? Recent research points to fat cells nearby. These fat cells change in ways that help cancer grow and spread. Normally, fat cells store energy. But in TNBC, they lose fat and become inflamed. This isn't good. The changed fat cells send signals to cancer cells...
Stomach cancer is a serious illness. It gets even trickier when it spreads to other parts of the body. This spreading, known as metastasis, makes treatment tough and affects how well patients do. Doctors and researchers are keen to understand how and where the cancer spreads. This knowledge can help them create better treatment plans and predict how patients will far...
Gastric cancer is a big deal. It's one of the most common cancers affecting the digestive system. Once it spreads, things get really tough. This is where a small protein called FNDC3B comes into play. It's a tiny helper that's been spotted in various tumors. But its role in stomach cancer? That's been a bit of a mystery until now. The big question is: How do...
The spread of colorectal cancer to the liver is a big problem. It often comes back after surgery. This might be because some cancer cells stick around and start growing again. These cells can be influenced by other factors in the body. Tumor-associated macrophages, or TAMs, are a type of immune cell. They are found in high numbers where cancer has spread to the live...
A new study has shaken up the way doctors might approach tongue cancer. It has uncovered a simple yet powerful tool for predicting how aggressive the cancer might be. The key? The ratio of the tumor's width to the tongue's width. This ratio could help doctors figure out if the cancer has spread to the lymph nodes in the neck. This is a big deal because knowing t...